International Research Journal of Pharmacy (IRJP) https://irjponline.com/index.php/IRJP PANhealth Care Research Society en-US International Research Journal of Pharmacy (IRJP) 2230-8407 THE ROLE OF HSCRP AS A MARKER IN PREDICTING HYPERTENSION IN MIDDLE AGED ADULTS https://irjponline.com/index.php/IRJP/article/view/3370 <p><strong>Introduction: </strong>Hypertension in a very prevalent disease of current times and is a risk factor of coronary artery disease and stroke. CRP is elevated in serum in response to variety of inflammatory stimuli. hsCRP is highly sensitive than CRP and can be detected even in low levels expressed in early stages of inflammation.&nbsp; <strong>&nbsp;&nbsp;</strong></p> <p><strong>Materials and Methods: </strong>The study comprised of total of 100 participants who were grouped as Group I comprising of 50 normotensive patients (&lt;140mmHg &amp; &lt;90mmHg) and Group II (&gt;140mmHg &amp; &gt;90mmHg) hypertensive patients. Patients in the age range of 40-60yrs were selected for the study.&nbsp; Patients with hypertensive complications, alcohol, oral contraception, post menopausal women, lactating mothers, prolonged systemic infections, injuries, prolonged medication were excluded from the study. Resting supine blood pressure was recoded using sphygmomanometer; palpatory and auscultatory method was used to record systolic and diastolic blood pressure. Venous blood samples were collected and serum was used to assess the serum hsCRP using ELISA kit. Mean±SD was used to represent continuous data and p value of &lt;0.05 was implied as statistically significant.&nbsp;</p> <p>The participants of the study were predominantly females (63) and in the age group of 18-60 years. The values of FBS, PPBS, HbA1c and Vit D were compared among Group I and Group II and were statistically significant. 36 patients of Group II had Vit D deficiency, 9 patients had insufficient Vit D and only 5 patients had sufficient Vit D. Vit D showed an inverse relationship with HbA1c more strongly than other parameters.</p> <p><strong>Results: </strong>Among 100 participants<strong> t</strong>here were a total of 45 males and 55 females in the present study in the age range of 40-60yrs. Majority of the participants in Group I were 50-55yrs and in Group II 55-60yrs (<strong>p&lt;0.001</strong>). The mean and standard deviation of BMI in Group I and II was 23.26±1.88 and 29.4±2.47 respectively (<strong>p&lt;0.001</strong>). The mean and standard deviation of pulse rate in Group I and II was 83± 6.59 and 81.84 ± 8.44 respectively (p=0.445). The systolic and diastolic blood pressure in Group I and Group II were 114.7±5.64 &amp; 75.7±8.34; 158.23±17.84 &amp; 95.68±9.87 (<strong>p&lt;0.001</strong>).&nbsp; Correlation of serum hsCRP level and blood pressure showed a positive R value of 0.2131 with systolic BP (<strong>p&lt;0.05</strong>) and 0.4132 with diastolic BP (<strong>p&lt;0.001</strong>). The serum hsCRP levels noted in Group I were 34 low risk, 10 intermediate risk and 6 high risk and in Group II were 2 low risk,17 intermediate risk and 31 high risk participants. The serum hsCRP level in Group I was 0.76±0.15 and in Group II 1.63±1.18 (<strong>p&lt;0.001</strong>).&nbsp;</p> <p><strong>Conclusion: </strong>hsCRP is readily available with long half-life hence can be used as a cost effective technique which can detect small quantities of CRP. Elevated levels of hsCRP can detect hypertensive changes in early stages hence can be considered as a marker of hypertensive patients with risk. Thus early detection of hypertension can prevent cardiovascular risk.&nbsp;&nbsp;</p> Vishaal S Copyright (c) 2024 2024-07-12 2024-07-12 15 7 1 12