A REVIEW ON METHODS OF SYNTHESIS OF 1,2,4-TRIAZOLE DERIVATIVES

Abstract

In the last few decades, heterocyclic compounds have been studied extensively owing to their interesting biological activities. One of them is triazole nucleus which exist in two isomeric forms: 1,2,3-triazole & 1,2,4-triazole. Out of which 1,2,4-triazole nucleus possess broad spectrum of pharmacological activities. This diversity in the pharmacological activity has attracted the attention of many researchers to explore the skeleton for its wide potential. This review summarizes the literature dealing with the conventional and green synthesis of 1,2,4-triazole nucleus.