A REVIEW ON CHITOSAN-BASED HYDROGLES FOR THE DRUG DELIVERY SYSTEM

Abstract

Chitosan is a natural polymer obtained by deacetylation of chitin. It is biologically safe, non-toxic, biocompatible and biodegradable polysaccharide. Chitosan is a good candidate for site-specific drug delivery. Hydro gels are potential candidates in controlled release applications. It is due to their soft tissue biocompatibility, the ease with which the drugs are dispersed in the matrix and high degree of control achieved by selecting physical and chemical properties of polymer network. The aim of this review is to provide insight into the applications of chitosan based hydro gels for the drug delivery through different routes. These chitosan-based hydro gels are very essential in the sustained release of antibiotics to reach the target site. This article reviews focused on entire features of chitosan-based hydrogles in both as a drug delivery matrix system and a system for tissue engineering as well as its potential therapeutic applications. Finally it can be concluded that chitosan-based hydro gels offers a novel way for the sustained release of drugs to treat localized infections.