EMERGING LIQUISOLID COMPACT TECHNOLOGY FOR SOLUBILITY ENHANCEMENT OF DRUG ROSUVASTATIN BCS CLASS-II

Abstract

The objective of the study was to increase the solubility, and dissolution rate of Rosuvastatin Calcium. The in vitro dissolution property of slightly
water soluble rosuvastatin calcium was improved by exploring the potential of Liquisolid system (LS). The in vitro release pattern of LS compacts and
directly compressed tablets were studied using USP-II apparatus. Different LS compacts were prepared using a mathematical model to calculate the
required quantities of powder and liquid ingredients to produce acceptably flowable and compressible admixture. Avicel PH 102, Aerosil 200, sodium
starch glycolate were employed as carrier, coating material and disintegrant respectively for preparing LS compacts. The prepared LS compacts were
evaluated for their flow properties such as bulk density, tapped density, angle of repose, Carr’s compressibility index and Hausner’s ratio. The drug
release rates of LS compacts were distinctly higher as compared to directly compressed tablets, which show significant benefit of LS in increasing
wetting properties and surface area of drug available for dissolution. The LS-6 of LS powder system showed acceptable flowability, Carr’s
compressibility index and Hausner’s ratio. From this study it concludes that the LS technique is a promising alternative for improvement of dissolution
property of water-insoluble drugs.