STUDY IN VITRO OF KETOPROFEN PATCH WITH TWEEN 80 AS ENHANCER

Abstract

Ketoprofen is an analgesic drug that can be made in transdermal patches based on its physical and chemical properties. Enhancer is used to increase drug permeation from patch to skin. Study was conducted on ketoprofen as transdermal patch using tween 80 as penetration enhancer. The formulas used were with variation of tween 80 concentration each 0%, 1%, 2%, and 3%. The patch was prepared by solvent evaporation method. Eudragit RS100 and PVP were used as polymer base and drug release controller. Evaluation of the preparation was done by in vitro permeation test using the Franz diffusion cell method with a shed snake of Phyton reticulatus as a membrane release membrane. The permeation test was carried out for 12 hours. The results showed increased permeation of ketoprofen which was comparable with the increasing concentration of tween 80. F4 formula containing 3% of tween 80 gave the largest percentage 60.14% of permeation in comparison to other formula F1, F2, and, F3. All formulas showed zero order kinetics.