FREE RADICAL SCAVENGING ACTIVITY OF EVOLVULUS ALSINOIDES ON GLUTAMATE INDUCED NEURODEGENERATION

Abstract

The whole plant extract of evolvulus alsinoides was evaluated for its antioxidant activity in glutamate induced neurodegeneration. The extract was given orally in to two different doses (200mg/kg and 400 mg/kg) for 7 days .Simultaneously rats were treated with monosodium glutamate (5mg/kg; i.p) and for comparison purpose NMDA antagonist memantine (5mg/kg) was used as a standard drug. Parameters under study were TBAR, SOD, Nitrates and protein. The orally administrated extracts and memantine (5mg/kg; i.p) significantly decrease nitrates, TBAR levels and significantly increase the SOD levels in glutamate treated groups. But the extract and memantine did not alter protein level in glutamate treated rats