SYNTHESIS, CHARACTERIZATION, AND ANTIBACTERIAL ACTIVITY OF SCHIFF BASES DERIVED FROM THIOSEMICARBAZIDE, 2-ACETYL THIOPHENE AND THIOPHENE-2 ALDEHYDE

Abstract

Two Schiff bases 2-acetylthiophene thiosemicarbazone (L1) and thiophene-2-aldehyde thiosemicarbazone (L2) were prepared in excellent yield via the condensation of 2-acetyl thiophene/ thiophene-2-aldehyde and thiosemicarbazide. The lead (II) and nickel (II) metal complexes of the Schiff base ligands ([Pb(L1)2]Cl2 and [Ni(L1)2]Cl2 were also prepared. The ligands and complexes were tested against gram- negative [E. Coli (MTCC No: 452)] and gram- positive bacterial strains Bacillus sp [(MTCC No: 297)] by using Kirby-Bauer’s method. The compound ([Pb(L1)2]Cl2 was found out to be more active against both bacterial strain (E. coli & Bacillus sp) having zone of inhibition12.45 ± 1.2 and 11.27 ± 1.1 mm respectively.