FORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF LEVOFLOXACIN

Abstract

Purpose: The objective of present study is to develop site-specific drug delivery system for controlled release of levofloxacin for eradication of H. pylori for the treatment of peptic ulcer. Methodology: Floating microspheres of Levofloxacin were prepared by solvent evaporation method. The drug was encapsulated with Eudragit and Ethyl cellulose in various combinations of polymers ratios. Findings: The prepared microspheres are subjected to evaluation for particle size, % buoyancy, in-vitro release study and stability studies. The percentage buoyancy was found to be in the range of 67.12% to 94.21%. The good buoyancy behaviour of the microspheres revealed that the microspheres are hollow in nature and retained for more than 12 hr in the upper part of the GIT in order to enhance gastric residence time. Research Implications: The prepared formulations can be tested clinically to assure the in vivo performance. Value of paper: The current study compared the combination of polymers and revealed their effect on drug release and various other parameters for the preparation of floating microspheres.