COMPARATIVE ANALYSIS OF OPHTHALMIC GEL FORMING POLYMERS ON THE DRUG RELEASE OF TIMOLOL MALEATE

Abstract

In this research work we have seen the effect of different polymers (Xanthan gum, carbopol, gellan gum) on in-vitro release profile of timolol maleate. Ophthalmic drug delivery is the best route of administration for the topical action at the ocular site. The main aim of designing a therapeutic system is to achieve the optimal concentration of a drug entity at the active site for the appropriate duration. Optimum rheological properties of gels increase the contact time by reducing the clearance due to the mucoadhesive property of the polymer used. Mostly gels exhibit pseudoplasticity; they cannot be easily delivered to the eye. The phase transition in the in-situ forming gel preparation can be induced by a pH shift as in case of Xanthan gum and by the presence of the de acetylated gellan gum). From this comparison studies we concluded that xanthan gum in a concentration of 0.4%w/v show the maximum drug release of timolol maleate and other parameters also it shows the best results. Thus, from experimental data, it is clear that the gellan gum and Carbopol can be replaced by xanthan gum polymer in gel forming solution. The viscosity of the formulation is also between the limits and can be tolerable by our eye which is further compared with innovator sample of gellan gum which shows 106cps at 90 RPM.