FORMULATION AND EVALUATION OF SUBLINGUAL FILM OF NATEGLINIDE

Abstract

Sublingual route is a very useful for rapid onset of action with better patient compliance. It provides better drug utilization and improves the efficacy of active pharmaceutical ingredients. The oral route is the most acceptable for patients. Fast dissolving oral drug delivery system is solid dosage form which disintegrates or dissolves within second when placed in the mouth without need of water or chewing. The current study presents the formulation aspects, manufacturing methods like solvent casting, evaluation parameters and applications of fast dissolving films by sublingual route by using polymers such as PVP K-30, PVA and PEG-400 as a plasticizer and Mannitol as a sweetener. A film formed in F3 formulation was transparent, smooth and homogenous with best film forming property among all the film forming agents.