PREFORMED GEL VS IN SITU GEL: A REVIEW

Abstract

In situ gel is a gelatinous solution when interacting with the eye due to changes in the physical properties of chemistry by the eye so as to not cause problems like the previous gel. Preformed gel usually consists of dried, crosslinked polyacrylamide powders. The objective of this study was to compare between preformed gel and in situ gel preparation. In this review is explained about comparing the advantages and disadvantages, mechanism of drug release, and polymers used in both these dosage forms. Currently there was a lot of progress in the field of dosage formulations. One of them was a hydrogel dosage form. Hydrogels were polymers that have the transition ability between the liquid-gel. There were two groups of preformed gels and in situ gel. Preformed gel and in situ gel which can increase the residence time and bioavailability.