WOUND HEALING EFFICACY OF HERBAL OINTMENT CONTAINING OLDENLANDIA HERBACEA ROXB. ON EXCISION WOUNDED ANIMALS

Abstract

Objective: The present study is aimed to evaluate the curative effect of herbal ointment containing Oldenlandia herbacea Roxb. against excision wound. Methods: Animals weighing 150 -200g were divided into five groups each comprising of six rats: Group I served disease control, Group II served as excision wounded control and Group III, IV served as excision wounded animals were treated with 10% and 20% of herbal ointment (HO) containing Oldenlandia herbacea Roxb. applied topically for 14days respectively and group V served as excision wounded animals treated with reference ointment soframycin. The healing of wound was assessed by the rate of wound contraction, level of hydroxyproline, hexosamine, tissue and serum protein, ascorbic acid, Deoxyribonucleic Acid (DNA), Ribonucleic Acid (RNA), Superoxide Dismutase (SOD), Lipid Peroxidation (LPO). Results: The topical application of herbal ointment treated groups showed increase in hydroxyproline, hexosamine, protein, DNA, RNA and SOD, Ascorbic acid and significant decrease in the wound contraction, LPO. Conclusion: The results concluded that the Oldenlandia herbacea Roxb has the efficacy in the management of wound healing.