AQUASOMES AS A CARRIER SYSTEM FOR ORAL DELIVERY OF BROMELAIN

Abstract

The aim of the present study was to investigate the aquasome as potential carriers for efficient oral delivery of Bromelain in order to improve its bioavailability. Aquasomes prepared by inorganic core of calcium phosphate covered with a sugar film and further adsorption of the Bromelain and characterized in terms of the morphological examination, particle size distribution, entrapment efficiency, drug loading and in vitro release. The surface morphology of the freeze-dried aquasomes were smooth, discrete with a regular spherical to near-spherical shape. Size of the aquasomes after freeze- drying was 473 mm and well-distributed. The zeta potential of microspheres was -11.1 mV. Entrapment efficiency and drug loading of different aquasome formulation was found to be 72.0±2.13 to 79.6±0.95 and 2.78±0.05 to 3.98±0.06 respectively. The cumulative release rate of bromelain aquasomes was followed by a sustained release. The release following Korsmeyer-Peppas Model and from the ‘n’ value we see that the release followed the Non-Fickian release mechanism. That means here the release is occurred by diffusion as well polymeric chain erosion.