A REVIEW ON CURCUMIN: WOUND HEALING PROPERTIES AND BIOMARKERS OF WOUND HEALING

Abstract

Turmeric (Curcuma longa), a rhizomatous perennial herb has been used from centuries for the treatment of rheumatism, diabetes, skin diseases, protozoal and fungal infections. Curcumin (diferuloylmethane), is the main curcuminoid responsible for imparting yellow color. It has caught attention since it is relatively safe, economical and owing to its multifaceted biological effects viz., anti-inflammatory, anti-oxidant, anti-carcinogenic and anti- infectious effects. Furthermore, wound healing properties of curcumin has received tremendous attention. It accelerates wound healing by exerting its action on various stages of wound repair. This review includes the in-vivo studies on the effect of curcumin. There is sufficient evidence on the wound healing effect of curcumin which provide proof for its positive effect on granulation tissue formation, collagen deposition and wound contraction. Further, the article includes various biomarkers used in the prediction of wound healing and wound infection. Thus, application of curcumin preferably topical application through modulation and optimization of formulation can confirm its therapeutic effects on skin wounds. Identification of a specific biomarker for wound healing could be a innovation in this field and for the treatment of impaired wound healing.