IN VIVO HAIR GROWTH STIMULATING ACTIVITY OF ETHANOL EXTRACT AND ITS FRACTIONS FROM RAMPAI LAMPUNG (LYCOPERSICON ESCULENTUM Mill.) LEAVES

Abstract

Hair loss is a hair problem that often occurs in every individual. Side effects caused by the use of synthetic drugs cause herbal remedies to be an option in overcoming hair loss and to stimulate hair growth. Rampai leaves (Lycopersicon esculentum Mill.) has traditionally been used to stimulate hair growth in the Lampung tribe. This study aim was to examine the activity of hair growth stimulation effects of ethanol extract and fraction (n-hexane, ethyl acetate, and water) from rampai leaves. The activity test of hair growth stimulation effect was carried out topically on New Zealand White (NZW) male rabbits for 21 days with the modified Tanaka method and using 2% minoxidil as a positive control The analysis results were evaluated statistically. The test results of ethanol extract of rampai leaves showed the most significant hair growth stimulation activity at 10% concentration, followed by a concentration of 20% and 5%. In testing the activity of fraction, n-hexane fraction significantly showed better hair growth activity compared to ethyl acetate, water fractions, and positive control. This showed that rampai leaves had vity of hair growth stimulation effects could be used as anti-alopecia treatment. Further experiments are needed to find the chemical compound content that is responsible for the nature of hair growth.