SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 6-SUBSTITUTED 2-AMINOBENZOTHIAZOLES
Keywords:
2-aminobenzothiazoles, arylidines, anthelmintic, antidiabetic, cytotoxic activity.Abstract
Heterocyclic compounds and analogues have attracted strong interest due to their biological and pharmacological properties. Nitrogen containing heterocyclics, Benzothiazoles are an important class of heterocyclic compounds and the nucleus containing compounds involved in research aimed at evaluating new products that possess biological activities such as antibacterial, antifungal, anthelmintic, antidiabetic, and anticancer agents. In the present study various derivatives of 6-substituted 2-aminobenzothiazoles were prepared and evaluated for their antibacterial, antifungal, antioxidant and cytotoxic activity by various standard methods. Among the synthesized compounds, most of the compounds exhibited potent activity when compared with that of the standard drugs. Hence the versatile synthetic applicability and biological activity of these heterocyclic compounds will help the chemist to plan, organize and implement new approaches towards discovery of novel derivatives of Benzothiazoles.
