FORMULATION AND EVALUTION OF ORALLY DISINTEGRATING TABLETS OF MECLIZINE HYDROCHLORIDE

Abstract

The objective of necessary work to develop meclizine HCl fast disintegrating tablet using different disintegrant which would disintegrate tablet rapidly in oral cavity. Nine batches of meclizine HCl orally disintegrating tablets were prepared by direct compression method using sodium starch glycolate, crosscarmellose sodium, Crospovidone as disintegrant in different concentration in order to achieve faster disintegration of tablet. The influence of the disintegrant concentration on the release of meclizine HCl was studied. The formulated batches were characterized by different physical parameters. Physical parameters of all formulated tablets were within acceptable limits. The study reveals that the formulation containing Crospovidone as disintegrant shows faster disintegration compare to others.