EFFECT OF POLYMERS AND PROCESSING METHOD ON PHYSICAL CHARACTERIZATION OF ORALLY DISINTEGRATING FILM
Keywords:
Orally disintegrating films, Freeze drying, Oven drying, Hydroxypropyl methylcellulose, Lycoat RS720.Abstract
The aim of this study was to investigate the effect of single polymer and their blends combination polymer and two different drying methods on the physical properties of orally disintegrating films (ODFs). ODFs were prepared by hydroxypropyl methylcellulose (HPMC) or Lycoat RS720 polymer and their blends using the solvent-casting method with Polyethylene glycol (PEG) 400 as a plasticizer. The prepared ODFs were dried by either oven drying (OD) or freeze-drying (FD) method prior to physical properties comparison. ODFs were cut and evaluated in terms of visual aspect, uniformity of weight, determination of thickness, in-vitro disintegration time, tensile strength, folding endurance, and surface morphology. Freeze drying can be considered as a method of choice to formulate ODFs due to rapid disintegration time of film produced. Formulation F8 from single polymer category and F20 from polymers blend category are chosen as optimum ODFs formulation with desired tensile strength 87.96±5.91 and 89.05±3.72, respectively and shortest in-vitro disintegration time 11.33±0.58 and 53.33±2.08, respectively.
