EVALUATION OF EFFICACY AND SAFETY OF PLATELET RICH PLASMA (PRP) IN THE TREATMENT OF ANDROGENIC ALOPECIA AND BACTERIAL ULCERATIVE LESION

Abstract

Background: Androgenic alopecia is the most common type of hair loss in both sexes, it is androgen dependent, genetically determined. Many therapies are used in the treatment of androgenic alopecia. Recently platelet rich plasma (PRP) is used as a constructive therapy for the treatment. Objectives: To evaluate the efficacy and safety of PRP in the treatment of androgenic alopecia, and bacterial ulcerative lesions in scalp. Patients and methods: Sixty- four patients with androgenic alopecia were included in this study; they were fully interrogated and examined for sex, age, grad and duration of alopecia and previous therapy. They were treated by injection of 4-5ml of prepared PRP from each patient in the bald area, and the patients followed up for 6- 12months after the last secession. Patients with ulcerative lesions developed secondary bacterial infection, and swabs were taken from them, and cultured on different culture media and submitted to a serial of different biochemical tests for diagnosis. Results: A total number of 64 patients with androgenic alopecia were treated by PRP injections, all patients show response with 30% growth of new hair, and negative pull test, increasing of thickness and growth of the hair, the efficacy was variable and directly proportion with the number of secession and inversely proportion with the duration of interval between the successful secession, without adverse side effects. Bacteriological study of those with secondary bacterial infections with S. aureus shows responsive for treatment with PRP. Conclusion: It was concluded that PRP therapy was an effective and safe method for the treatment of androgenic alopecia in both sexes, without adverse side effects, and the prevalence was relatively common in both sex, according to antimicrobial activity of PRP against S. aureus and S. pyogenes