STUDY THE RISK FACTORS, BACTERIAL PROFILE AND ANTIBIOTIC RESISTANCE PATTERN IN URINARY TRACT INFECTIONS PEDIATRIC IRAQI PATIENTS

Abstract

Urinary tract infection (UTI) in pediatric patients is a significant source of morbidity and considerable mortality. There are multiple risk factors as well as wide range of pathogen that associated with recurrent UTI. So, this study aims to determine the risk factor in UTI patients then isolation and identification causative pathogens with determination antibiotic resistance profile. A total of one hundred clinical samples from UTI – pediatric patients attending to Baghdad teaching hospitals during 1-5 till 1-12 /2017 were included. The study shows that Female sex, lack of circumcision, vesico-ureteral reflux (VUR), neurogenic bladder (NB), urinary tract abnormalities and inadequate water intake had significant effect on recurrent UTI. The results revealed that 86 bacterial isolate were gave positive bacterial growth, from which 52 were Gram negative bacteria that represent by 30(57.6%) E .coli isolate followed by 11(21.15) K.pneumonia isolate and 8(15.38%) isolates Proteus sp finally 3(5.76%) P.aeruginosa while gram-positive bacteria that comprised 34 (39.5%) divided into 12 (35) isolate were S.aureus, S.saprophyticus and 10 (30 %) isolate were Enterococcus sp. Antibiotic resistance profile confirmed that all uropathogens were multidrug resistance, 100% resistance toward Amoxicillin and show variable resistance toward Cephalosporins, Quinolones and sulfa drugs while the Imipenem and Vancomycin consider drug of choice in treatment. In conclusion, risk factors had a significant role in recurrent UTI. So precise diagnosis to causative agents and susceptibility pattern increase the success of therapy and prevent complication of disease