ANTI DIABETIC ACTIVITY OF ETHANOL EXTRACT OF RANGGAP BANANAS (MUSA TROGLODYTARUM L.)

Abstract

Traditionally, Fei banana or ranggap banana (Musa Troglodytarum L) was used for anti-diabetes treatment at Mount Galunggung, West Java. The purpose of this study was to verify the antidiabetic activity of the ethanol extract of ranggap banana. The study began with the collection of ingredients, maceration, phytochemical screening, and antidiabetic testing of male mice with the alloxan method. All mice measured initial fasting blood glucose levels first, then injected with alloxan at a dose of 145 mg/kg BW as subcutaneous. Then the antidiabetic effect was tested by dividing 7 male white mice (each group consisted of 3 mice), 2%), negative control (PGA 2% + alloxan), positive control, (PGA 2% + alloxan + glibenclamide 0.45 mg / kg BW and four test groups (PGA 2% + alloxan + test 1 (50 mg/200g BW), PGA 2% + alloxan + test 2 (100 mg/200g BW, PGA 2% + alloxan + test 3 (150 mg / 200g BW), and PGA 2% + alloxan + test 4 (200 mg/200g BW). The results showed that test 3 had the best effect of antidiabetic activity on decreasing blood glucose levels in mice meaning the Fei bananas had the potential for antidiabetic treatment. It is recommended to determine the structured content to find out which compounds are efficacious for antidiabetic.