SCREENING OF ANTICONVULSANT ACTIVITY OF KUSHMANDA FRUIT (BENINCASA HISPIDA THUMB) IN ALBINO RATS

Abstract

The aim of the present study was to evaluate the anticonvulsant activity of juice and aqueous extract of Benincasa hispida Thumb fruit in Albino Rats. Two drug samples were prepared i.e. Benincasa hispida fruit juice and aqueous extract. MES Model was adopted to observe the seizure control activity of tested drug. Flexion, clonus, recovery time, duration of tonic hind leg extension and onset of stupor were observed. Preliminary Phytochemical analysis revealed presence of Steroids, Alkaloids, Starch, Hexosugars, Monosaccharide’s and Proteins. Swarasa (Juice) at the dose of 0.9 ml/200 gm of rat shows significant protection against the shock induced convulsions (Significant at the level of P<0.05). Aqueous extract at dose 100mg/200 gm of rat shown lesser protection compare to the Swarasa (Significant at the level P<0.05). Nasal and orbital bleeding is observed in control and standard group but it is absent in test groups. Study reveals Benincasa hispida fruit juice possesses anticonvulsant activity