IN-VIVO EVALUATION OF ORODISPERSIBLE FILM OF ALLIUM SATIVUM LINN. IN COLON TUMOUR INDUCED MICE
Keywords:
Stabilized garlic extract, Orodispersible film, “In-Vivo” (Colon – 26), Allium sativum.Abstract
The present study emphasizes on In-Vivo evaluation of tumour suppressive activity of Orodispersible film formulation containing stabilized garlic extract of Allium sativum Linn. on colon tumour induced mice (Colon – 26). Initially “In-Vitro” activity was performed on two different cancer cell lines like human colon cancer cell line (COLO 205) and human prostate cancer cell line (PC-3). For further “In-Vivo” activity evaluation colon tumour induced mice (Colon – 26) were selected based on results of different “In-Vitro” cell lines studied. As compared to reference drug, Adriamycin (Doxorubicin) of allopathic origin, orodispersible film formulation containing stabilized garlic extract of Allium sativum of natural origin shows comparable tumour suppressive activity on long term dose. Hence orodispersible film formulation containing stabilized garlic extract of Allium sativum will be a useful nutraceutical for cancer prevention, mitigation and to avoid re-occurrence of cancer. Above orodispersible film formulation possesses significant anticancer activity, to warrant further tumour suppressive activity shall be done on human volunteers to determine precise safety, efficacy, pharmacokinetic and pharmaco-dynamics.
