QUINAZOLINONE: AN OVERVIEW

Abstract

Quinazolinone is a heterocyclic compound with a unique place in the field of medicnal chemistry. This quinazolinone has gain importance as antimicrobial, anti-inflammatory, anticonvulsant, analgesic, antihypertensive, antihyperlipidemic, diuretic, sedative, anticoccidial activity, antitubercular, antiviral, and anticancer agent. The chemistry of quinazolinone compounds has been the subject of considerable interest though there had been only scattered reports of the investigation of the medicinal properties of such compounds. This broad spectrum of biological and biochemical activities has been further facilitated by the synthetic versatility of quinazolinone which allows the generation of a large number of structurally diverse derivatives. This includes numerous analogues derived from substitution of the quinazolinone ring system, and derivatization of quinoline ring structure. Quinazolinone based drugs have broadened scope in remedying various dispositions in clinical medicines. Some quinazolinone derivatives have better activity than standard drugs and could become a new drugs for the market in future. Quinazolinone was proved to be useful in diuretic, anticancer, antihypertensive, NSAID, cardiovascular, hypnotic and antifolate drug discovery. This comprehensive study summarizes the different derivatives of substituted quinazolinone along with their chemistry, biological evaluation, and their major applications in the field of medicine and provide base for the future research work regarding modifications in quinazolinone moiety and its implementation in drug discovery and drug development.