KINETIC AND MECHANISTIC STUDY OF OXIDATION OF ATENOLOL BY CERIUM (IV) IN SULPHURIC ACIDIC MEDIUM

Abstract

The kinetics of oxidation of antihypertensive drug, atenolol by cerium (IV) in sulphuric acidic medium has been studied spectrophotometrically at 360 nm. The reaction between cerium (IV) and atenolol in acidic medium has exhibited 2:1 stoichiometry. The order of the reaction with respect to atenolol has been found to be one. The observed pseudo first order rate constants kobs increased with sulphuric acid and hydrogen ion concentrations where as decreased bisulphate ion concentration indicating the formation bisulphato reactive species of cerium (IV) in the present reaction. The thermodynamic parameters have been evaluated from the temperature variation kinetic data. A possible mechanism is proposed which has been validated by derived rate law. An attempt has been made to use rate data for kinetic estimation of atenolol.