INTRINSICALLY DISORDERED PROTEINS (IDPs) IN HUMAN DISEASES: A REVIEW

Abstract

Biologically active proteins without stable tertiary structure are called Intrinsically Disordered Proteins (IDPs) or Intrinsically Unstructured Proteins (IUPs). These IDPs are highly abundant in nature and are involved in regulation, signaling, and control. Structures and functions of IDPs are controlled and modulated by alternative splicing and posttranslational modifications. Many proteins associated with human diseases are IDPs. Each of these diseases originates from the misfolding or dysfunction of a specific protein. This review presents some of the IDPs involved in human diseases.