CURRENT TRENDS IN DRUG DISCOVERY: TARGET IDENTIFICATION TO CLINICAL DEVELOPMENT OF THE DRUG

Abstract

The practice of the drug discovery process has been revolutionized with the involvement of some newer techniques. Target based drug design is more advantageous, time consuming and effective. With the use of High Throughput Screening (HTS) technique a large number of compounds screened for their biological activity with the discovered)) target, which are synthesized by combinatorial chemistry, these are called hits. Quantitative Structure Activity Relationships (QSAR) constitutes immense importance in discovering new drug candidate called analogues which shows high affinity with the target. Various advanced techniques and Modern research disciplines such as genomics, proteomics, metabolomics, chemogenomics, and others improve the quality of the drug discovery process. The main objective of this article is to highlight the steps and trends followed in drug discovery process and also to understand the mechanism for searching the ailment of disease.