DESIGN AND OPTIMIZATION OF NOVEL SELF NANOEMULSIFYING FORMULATION OF ETODOLAC

Abstract

The objective of the study is to develop and optimize self nanoemulsifying drug delivery systems (SNEDDS) of Etodolac. Among the oils and surfactants studied, Phosal 53 MCT, Labrasol and PEG 400 were selected as they showed maximal solubility to Etodolac. The ternary phase diagram was constructed to find out the region forming Microemulsion. The optimized liquid SNEDDS formulation consisted of Phosal 53 MCT, Labrasol and PEG 400 as oil, surfactant and cosurfactant. Self emulsification time, % Transmittance and Relative turbidity were used as variables for optimizing the Liquid SNEDDS formulation based on Box Behnken Design. L-SNEDDS formulation was evaluated for various studies including globule size analysis, TEM and in vitro dissolution study. The results suggested that the Self emulsifying formulation can enhance the dissolution of poorly soluble drug and has a potential to enhance drug absorption and improve bioavailability of drug.