SYNTHESIS, CHARACTERISATION AND IN SILICO ANALYSIS OF 4-(4- (DIMETHYLAMINO)PHENYL)- 6-ETHYL-1,3-DIPHENYLPIPERIDIN 2-ONE AS AN INHIBITOR OF COLON CANCER

Abstract

Aim: To evaluate the potential of the currently synthesized molecule for its biological significance with reference to anticancer activity. Cancer is one of the most feared and deadliest diseases in the world. The drugs for this disease are still being framed for different cases. CDK5 is found to have significant role in various diseases like neuronal cell survival and death, migration and also cancer. Small molecules as ligands of natural origin and those synthesized form laboratories are on the rise. Methods: The present work deals with the computational analysis of a synthetic compound as a ligand with anticancer activity. The molecule is analysed for its druggable property and biological significance using several softwares. The molecule was docked with the receptor protein bearing the PDB ID 1UNG. The pharmacophore features are also analysed. Results: The computational analysis show that the molecule possesses anticancer activity and the work has been discussed.