EVALUATION OF NEUROLEPTIC ACTIVITY OF PIPERINE ON PSYCHOSIS INDUCED SWISS ALBINO MICE

Abstract

Psychosis is defined as an abnormal condition of the mind that results in the difficulties telling what is real or what is not. According to the statistics in United States 3% of people develops psychosis at some point in time. In this present study we are going to compare pipernin with the standard drug Aripiprazole. For this we are taking 30 mice which are divided into 5 groups, each group consists of 6 mice. Group 1 is used as normal to which a dose of tween 80(vehicle) 1%v/v was given, group 2 mice are given Amphetamine 2.5mg/kg body wt. for inducing psychosis, group 3 animals are used as standard by giving them 0.5ml Aripiprazole through intra venal route, the group 4 and group 5 animals are used as test which are given different doses of pipernin. A dose of 20mg/kg is given to group 4 and a dose of 40mg/kg is given to group 5. The main parameters that are observed are stereotypic behavior of mice, Locomotory activity of mice, biochemical estimation and cataleptic activity. The results that are observed are in stereotypic behavior is number of sniffing is reduced. Locomotory time was reduced. Catalepsy has shown significant mean cataleptic course. Pipernin 40mg/kg has shown activity almost equal to standard and normal. The biochemical parameter estimated is dopamine in frontal cortex. 40mg/kg has reduced dopamine levels significant compared to that of normal and standard. Further study is required in order to evaluate mechanism of action and drug interaction in pipernin.