DEVELOPMENT OF FORMULATION AND EVALUATION OF GARLIC ORODISPERSIBLE FILMS
Keywords:
Allium sativum, Orodispersible film, METHOCEL E3 Premium LV, Glycerin, Factorial Design.Abstract
The present study emphasizes on development and evaluation of orodispersible film formulation containing stabilized garlic extract of Allium sativum Linn. prepared by solvent casting method. Drug-excipients interaction was studied by Fourier transform infrared spectroscopy and Differential scanning calorimetry which shows that concentrated garlic extract and excipients are compatible to each other. Initially three preliminary trials – P1, P2 and P3 were taken by varying concentration of Hypromellose (METHOCEL E3 Premium LV) and Glycerin (Pricerine 9093) and Macrogol 400. P2 formulation was found suitable for further optimization. Amongst them METHOCEL E3 Premium LV and Glycerin (PRICERINE 9093) were selected for further optimization of formulation (E1 to E9 formulations) by 32 Factorial Design. Formulation E8 was found to be optimized formulation with 35.56% w/w of Hypromellose (METHOCEL E3 Premium LV) and 3.33% w/w Glycerin (PRICERINE 9093). The E8 optimized garlic orodispersible film formulation was evaluated for stability studies and analysed for physical and mechanical properties. It was found that there were no significant changes in chemical, physical and mechanical properties.
