FORMULATION AND EVALUATION OF OXICONAZOLE BASED NIOSOMAL GEL FOR THE EFFECTIVE FUNGAL TREATMENT

Abstract

Niosomes are significant towards drug delivery potential and increase drug efficacy as compared to other form of drug delivery. Niosomes are highly stable and cost effective towards the treatment of targeted drug delivery. Therapeutic efficacy of the drug molecules can be improved by prolonging the release rate of active drug in systemic circulation and also protecting the drug from biological environment. Niosome appears to be a well preferred drug delivery system and potential for targeted delivery in anti-cancer, antifungal agents etc. This article focuses on to formulate oxiconazole based niosome gels for antifungal infection. Different types of polymers have been used to prepare oxiconazole based niosome gels. Drug polymer compatibility study carried out by FTIR and DSC techniques. Lipid hydration method is used for the preparation of multilamellar vesicles of niosomes.TEM and SEM analysis technique is used to confirm the particle size, shape and morphology of the prepared niosome gel. Nano sized niosomes easily penetrate through skin pores and polyethylene glycol used as penetrating enhancer. Formulated niosome gels subjected for evaluation study. Dissolution study confirms that formulation N15 has shown better result in controlling oxiconazole up to 98% in 12h. The kinetic release study follows non fickian behavior. Formulation N15 subjected for ex vivo diffusion study and shows optimum release rate whereas in vivo study with commercially available oxiconazole gel reveals better results with formulated niosome gel as it transforms the infected part of the skin like a normal skin