INTERPOLYELECTROLYTE COMPLEXES AS PROSPECTIVE CARRIERS FOR CONTROLLED DRUG DELIVERY

Abstract

In the current scenario, polymers as carriers have revolutionized the drug delivery system. A more successful approach, to exploit the different properties of polymers in a solitary system is the complexation of polymers to form polyelectrolyte complexes. These complexes circumvent the use of chemical crosslinking agents, thereby reducing the risk of toxicity. The complex formed is generally applied in different dosage forms for the formulation of stable aggregated macromolecules. There are two structural models for polyelectrolyte complexes - ladder like structure and scrambled egg model. Number of factors affects the formation and stability of polyelectrolyte complex. Polyelectrolyte complexes have been classified on the basis of type of macromolecules and the interaction forces involved in complex formation. Polyelectrolyte complexes have aroused as an emerging system to deliver drug at target sites, controlling the release rate of drug by acting as carriers and thereby prolonging the therapeutic action. They can be used as coating films for binding pharmaceutical products and in preparation of microcapsules. Complexation between selected natural and synthetic polymers and the applicability of complexes as in nanoparticles, microparticles, buccal films, sponges and matrix type tablets is discussed. The present review emphasizes entirely on polyelectrolyte complexes, their classification, formation, characterization, utilization and future perspectives in concern to optimal drug delivery system