PREPARATION AND CHARACTERIZATION OF NARINGENIN GOLD NANO SUSPENSION FOR BREAST CANCER

Abstract

Breast cancer is world third leading cause of death in the world among women. Breast cancer is spreads from milk duct. Nano particle based formulation such as nano suspension enhance therapeutic effectiveness and reduce side effect of the drug payload by improving their bioavailability and improves the efficacy of cancer therapeutically. Naringenin is targets breast cancer cell by targeting estrogenic receptors. Bottom –Up approach was used. for preparation of naringenin gold nano suspension (NGNS).Gold has its own surface Plasmon resonance property, which targets the cell by combining with naringenin. Naringenin gold nano suspension solid particles were obtained by lyophilisation. Optimized batch of the NGNS shows the particle size by Dynamic light scattering 179.7±4.9nm with poly dispersity index of 0.28 ± 0.02.NGNS shows zeta potential -28.53±0.17. TEM image of the NGNS was show particle size of 160.7nm. The results suggested that precipitation was an effective way to prepare NGNS improves the dissolution rate for targeting cancer cells.