PHARMACOLOGICAL SCREENING OF SOME NEW AMINOPYRIDINIUM DERIVATIVES

Abstract

Aminopyridinium derivative such as Ethyl-2-(4-chloroamino pyridinium) acetate (compound A),Ethyl-2-(4-bromoamino pyridinium) acetate (compound B), Ethyl-2-(3-chloroaminopyridinium) acetate (compound C) have been evaluated for analgesic, anti anxiety and locomotor activity. All the aminopyridinium derivative prepared by the dose (50&100mg/kg/i.p), which shown significant analgesic activity when compared to morphine (5mg/kg/i.p).In case of open field exploratory and elevated plus maze test, the aminopyridinium derivatives prepared by the dose( 50&100mg/Kg/oral) reverse the anxiety behavior of the mice when compared to lorazepam (0.5mg/kg/oral). Among this, compound C (100/mg/kg) produce better effect than others. Locomotor activity in the activity cage, the reaction time of Aminopyridinium derivative A, B&C produce more effective Central nerve depressant effect than Diazepam (2mg/kg/i.p) drug.