FABRICATION AND CHARACTERIZATION OF GASTRORETENTIVE MUCOADHESIVE MICRO-PARTICULATE SYSTEM OF PIOGLITAZONE HYDROCHLORIDE FOR SUSTAINED DELIVERY

Abstract

The present study was conducted to formulate and evaluate Gastro retentive Micro-particulate drug delivery system of Pioglitazone Hydrochloride (HCl) for sustained delivery. Pioglitazone Hydrochloride microspheres were prepared by Orifice-Ionotropic Gelation method using a blend of sodium alginate and different mucoadhesive polymers such as Carbopol 934P, Hydroxy Propyl Methyl Cellulose (HPMC, E 50 Low Viscosity) and Sodium Carboxy Methyl Cellulose (SCMC). Totally 16 different formulations of Pioglitazone Hydrochloride were prepared. The microspheres were characterized for Percentage yield, Micromeritic properties, Particle size, entrapment efficiency, shape and surface morphology studies by Scanning Electron Microscope, mucoadhesivity, swelling index, in-vitro drug release and stability studies. The resulting microspheres were small, discrete, spherical and free flowing. Entrapment Efficiency of Pioglitazone Hydrochloride was found to be between 55 % - 106 %. Release was sustained for up to 8 hours. The kinetic modelling of the release data indicate that Pioglitazone hydrochloride release from the alginate microspheres followed first order kinetics and the drug release mechanism was found to be Fickian diffusion erosion controlled. Gastro retentive Microspheres of Pioglitazone Hydrochloride is a potential Sustained release drug delivery system for increasing the efficiency of the dose as well as the patient compliance.