RECENT TRENDS IN DPI TECHNOLOGY

Abstract

DPI device presents medication to the patient as a dry powder in a form that can be inhaled orally for delivery to the target lung tissues. DPIs are bolus drug delivery devices that contain solid drug, suspended or dissolved in a non polar volatile propellant or in a dry powder mix (DPI) that is fluidized when the patient inhales. drug is inhaled as a cloud of a fine particles. The primary factor influencing the manufacture of DPI powders is the need to produce material that can penetrate into the lung. Development of various approaches to the controlled production of fine particles, primarily depending on the nature of the drug. Of the processes micronization and blending and, more recently, spray drying are used most often. Package dose metering can be accomplished by weight or by volume. Dry powders developed for DPIs are formulated to deliver a specific dose of drug per a given unit of drug powder. Drug powders can be packaged either in unit dose or in reservoir systems.