FLOATING MULTI-PARTICULATE ORAL DRUG DELIVERY SYSTEM: A REVIEW

Abstract

The purpose of this review on floating drug delivery systems is the recent literature with mechanism to achieve gastric retention by floatation. Gastroretentive drug delivery system have advantages besides providing better bioavailability to poorly absorbed drugs and a required release profile thus attracting interest of pharmaceutical formulation. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form. The objectives of the review discuss various parameters affecting the behavior of floating multiparticulate oral dosage form and to focus on the recent advances in the field of formulation, characterization, evaluation and applications of floating multi-particulates drug delivery. A large number of marketed formulations are formulated as gastroretentive dosage forms. Floating multi-particulates is one among the several approaches to gastroretention, like flotation, mucoadhesion, sedimentation, expansion, modified shape systems etc. The review also highlights the advantages with reference to the multi-particulate systems, as well as provides an overview of the future prospective that can take place in this arena.