LIQUISOLID TECHNIQUE: A NOVEL APPROACH TO ENHANCE SOLUBILITY AND BIOAVAILABILITY OF BCS-II DRUGS

Abstract

Liquisolid technique is new and promising method that can enhance the dissolution rate of poorly water soluble drugs. At present 56% of the drugs coming directly from synthesis are poorly water soluble drugs. The enhancement of oral bioavailability of poorly water soluble drugs is one of the challenging aspects of drug development. Liquisolid technique is based upon the dissolving the drug in a suitable non-volatile solvent and admixture of drug loaded solutions with appropriate carrier and coating materials to convert into acceptable flowing and compressible powders. By applying the mathematical models the carrier and coating materials optimized. In this case the drug is almost solubilised in the solvent or molecularly dispersed state which contributes the enhanced drug dissolution.