IN VITRO COMPARATIVE STUDIES ON SUSCEPTIBILITY PATTERNS OF PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS TO CEFEPIME AND CEFPIROME

Abstract

The aim of this study was to gather the epidemiological data on the susceptibility patterns of Pseudomonas aeruginosa and staphylococcus aureus against fourth generation cephalosporins (Cefpirome and Cefepime). Total 100 isolates of each bacterial species were collected from central laboratories of different private hospitals of Karachi, Pakistan between September 2012 and December 2012. Modified Kirby-Bauer disc diffusion method was used for the determination of sensitivity of Cefpirome and Cefepime using strains of Pseudomonas aeruginosa (ATCC 27853) and staphylococcus aureus (ATCC 6538) as control. In-vitro comparative susceptibility patterns of Cefpirome and Cefepime were studied. Isolates of Pseudomonas aeruginosa were found to be resistant, 15% against Cefepime and 18% against Cefpirome while that of staphylococcus aureus were 3% against Cefepime and 5% against Cefpirome. Results clarify that Pseudomonas aeruginosa is more resistant as compare to staphylococcus aureus against both of the fourth generation cephalosporins. It is concluded from this study that Cefepime and Cefpirome are highly effective against Pseudomonas aeruginosa and Staphylococcus aureus and can be used safely in the treatment of infections caused by these organisms.