APPRAISING THE FUNCTIONS OF AS A BIOMARKER OF INSULIN RESISTANCE IN VITILIGO VULGARIS PATIENTS

Abstract

Background: Vitiligo is a prevalent skin disorders that affects a wide population. It is characterised by the selective death of melanocytes. There is a dearth of information in the literature about trustworthy indicators of insulin resistance in vitiligo patients.

Aim: The purpose of this study was to evaluate the role of blood desnutrin as an insulin resistance biomarker in vitiligo vulgaris patients.

Methods: Ninety people with vitiligo vulgaris of both genders were evaluated and tested against ninety age- and gender- matched controls. In addition to measuring serum desnutrin, fasting serum insulin, LDL, VLDL, HDL, triglycerides, cholesterol, and FBG (fasting blood glucose), a thorough cutaneous and general examination was performed on each individual. Also, HOMA-IR (Homeostasis Model Assessment + insulin resistance) was done for all the participants.

Results: The participants with vitiligo vulgaris showed a statistically significant difference (p<0.001) in serum desnutrin, HOMA-IR, fasting insulin, FBG, and HDL when compared to the controls. Additionally, there was a p-value of less than

• for desnutrin and HOMA-IR, fasting insulin, VLDL, LDL, and FBS. There was a non-significant but favourable connection between HDL and desnutrin levels (p=0.06).

Conclusion: The current study concludes that subjects with vitiligo vulgaris exhibit suppressed serum desnutrin levels, which are a biomarker of insulin resistance in these subjects due to elevated serum insulin and glucose levels that cause insulin resistance and hyperlipidemia.