ANALYSING EFFICACY AND ASSESSMENT OF VITAMIN D LEVEL AND THYROID PROFILE TO DETERMINE THE INTENSITY OF FEMALE INFERTILITY

Abstract

Background: Thyroid dysfunction is a significant factor in the evaluation of infertility since it is linked to increased morbidity, lower fecundity, anovulatory cycles, and menstrual irregularities.

Aim: The purpose of this study was to analyze female infertility by measuring blood levels of vitamin D and thyroid profile.

Methods: Infertility was diagnosed based on the medical history of the individual who was unable to conceive after a year of regular sexual activity in individuals who did not have any concomitant systemic disorders such as diabetes, hypertension, or cardiovascular diseases. Thyroid and vitamin D profiles were measured in 96 fertile controls and 48 infertile females in the research.

Results: The values of vitamin D were shown to be 13.7±7.67, whereas the controls had considerably higher levels (20.7±6.45) (p<0.01). Regarding vitamin D insufficiency, it was observed that 22.83% (n=10) patients and 32.29% (n=31) controls had mild deficit, 33.33% (n=16) cases and 7.29% (n=7) controls had moderate deficiency, and 22.91% (n=11) cases and 2.08% (n=2) controls had severe deficiency. About the thyroid profile of the fertile and infertile females, it was observed that the TSH level was significantly higher in the cases (6.42±1.04) with p<0.01, T4 levels were significantly higher in the controls (6.41±2.06) than in the cases (5.2±3.54), and T3 levels were significantly higher in the controls (0.93±0.26) than in the cases (0.72±0.55) with p<0.01.

Conclusion: The current study comes to the conclusion that vitamin D and TSH levels were shown to be negatively correlated with female infertility. Thyroid profile and vitamin D levels should be routinely checked on all participants who are female infertile.