ANALYZING SERUM PROGESTERONE LEVEL IN INDIAN WOMEN DURING THREE TRIMESTERS OF NORMAL PREGNANCY AT REFERENCE INTERVALS

Abstract

Background: For both the mother and the fetus, the hormonal milieu throughout pregnancy becomes a critical predictor. A certain hormone concentration evaluated at each trimester can be a good predictor of feto-maternal outcomes.

Aim: The purpose of this study was to evaluate the reference range for a trimester-specific progesterone assay in healthy pregnant Indian women.

Methodology: The study comprised 138 pregnant women in good health who were in all three trimesters of their pregnancy. The included subjects' serum progesterone levels were measured using an enzyme-linked immunosorbent assay (ELISA).

Results: The study's female participants' progesterone range and interval were evaluated for each trimester of pregnancy. The results showed that the upper limit for progesterone in the first trimester was 93.07 ng/ml, the upper limit for the second trimester was 247.65 ng/ml, and the upper limit for the third trimester was 908.85 ng/ml. For the first, second, and third trimesters, the corresponding confidence intervals were 73.11-119.04, 181.90-333.90, and 745.04-1084.22. In the first, second, and third trimesters of pregnancy, the lower limit for progesterone was 5.47, 6.55, and 95.54 ng/ml. For the study individuals, the corresponding confidence intervals for the lower limit were 4.45-6.93, 5.20-8.59, and 80.22-117.47 for the first, second, and third trimesters of pregnancy, respectively.

Conclusion: The current investigation reveals that there is a significant discrepancy between the progesterone values observed in healthy Indian females and the defined reference range. The current study's findings indicate that serum progesterone levels gradually rise during pregnancy.