ASSESSMENT AND EFFECTS OF IPPA AND ITS DESIGNS ON PEOPLE WITH ULCERATIVE COLITIS AND CONCOMITANT PSC, AS WELL AS THE INCIDENCE OF NEOPLASIA IN IPAA PARTICIPANTS AND THE RESULTS OF IRA AND IPAA

Abstract

Background: One of the most recommended treatments for ulcerative colitis is IPAA. It is, nonetheless, linked to a number of difficulties, some of which may manifest early on. These early problems, which occur in 30–50% of patients, are similar to those observed in abdominal procedures. Following IPAA surgery, late problems might appear more than 90 days later.

Aim: The purpose of the current clinical investigation was to assess the effects of IPPA and its designs on people with ulcerative colitis and concomitant PSC, as well as the incidence of neoplasia in IPAA participants and the results of IRA and IPAA.

Methods: 186 participants' demographics, medical histories, physical examinations, diagnoses, surgeries, functional results, histology, related problems, and failures were recorded. Recorded were the Pouchitis, Proctitis, Endoscopy, and Pouch Functional Score. Evaluations of complications after IPAA or IRA were also conducted. The gathered information was statistically assessed, and conclusions were drawn.

Results: Bowel movement throughout the day was graded as 0, 1, and 2 in 28.94% (n=11), 50% (n=19), and 15.78% (n=6) participants with UC and in 28.57% (n=2), 0, and 71.42% (n=5) subjects with UC and PSC, respectively, after receiving IPAA therapy. Of the participants with UC and PSC, 12.5% (n=2) had pouchitis- related failure. In 12.90% (n=4) of the participants with UC alone and 62.5% (n=10) of the subjects with UC plus PSC, there were more than four episodes of pouchitis.

Conclusion: K-pouch with stapled anastomosing had the greatest long-term functional results in patients with ulcerative colitis and had a very low incidence of neoplasia after treatment. Subjects receiving IRA treatment for PSC and UC had high failure rates and reduced functional results. Nonetheless, IPAA demonstrated similar results in those with UC alone or UC combined with PSC.