COMPARISON OF CURB-65 SCORES IN NON-DIABETIC AND DIABETIC SUBJECTS HOSPITALIZED FOR COVID-19 INFECTION

Abstract

ABSTRACT

Background: Because diabetics are more susceptible to infections from a variety of bacteria and viruses, including respiratory tract infections, diabetes mellitus has been identified as a contributing factor for comorbidity in people with COVID-19. Out of all the scoring systems designed to evaluate CAP risk, CURB 65 ratings are the simpler one.

Aim: The purpose of this study is to document and evaluate the differences in CURB-65 scores between non- diabetic and diabetic patients admitted to an Indian hospital due to COVID-19 infection.

Methods: CURB-65 scores and glycemic status were assessed in 280 patients who were admitted due to COVID-19 infection. Based on the CURB-65 score, the participants were classified as having mild, moderate, or severe diseases. In addition, assessments were made on death rates, length of hospital stay, ventilator requirements, and ICU admission. Every participant was monitored until their early discharge or death.

Results: Of the participants with diabetes, 65.21% (n = 90) had mild CURB-65, while 97.18% (n = 138) did not. CURB-65 scores were moderate in 30.43% (n=42) of diabetes patients and 2.81% (n=4) of non-diabetic subjects. 24.63% (n=34) of the diabetes participants and 5.63% (n=8) of the non-diabetic subjects required ICU hospitalization (p=0.002). In the study, 4.22% (n=6) of the non-diabetic participants and 18.84% (n=26) of the diabetic subjects required ventilatory assistance. With p=0.007, this difference was statistically significant. Among the participants without diabetes, 24.63% (n=34) died (p<0.0001). For diabetes participants, the mean length of hospital stay was 9.23±5.2 days, while for non-diabetic subjects, it was 7.03±4.28 days (p=0.005).

Conclusion: Compared to non-diabetic participants with COVID-19 infection, people with diabetes mellitus showed greater and increased values of CURB-65 scores. Additionally, compared to non-diabetics, persons with COVID-19 and diabetes mellitus had worse disease severity.