EVALUATION THE CLINICAL EFFECTS AND AUDIT OF INTRODUCING AN Research Article

Abstract

ABSTRACT

Background: Because antibiotics are widely used for the admission of postoperative patients to intensive care units (ICUs) and because a significant number of sepsis cases are treated there, which can lead to antibiotic resistance in patients who are very sick, mortality and the severity of the disease are reduced with appropriate antibiotic therapy started on time, especially in ICUs.

Objectives: This study evaluated the clinical effects and audit of introducing an antibiotic stewardship program in patients hospitalized to adult surgical intensive care units in India.

Methods: An expert pharmacist audited the antibiotic regimens provided to surgical ICU patients, determining whether or not they were suitable. A microbiologist provided advice on antibiotic susceptibility and appropriate use, while a doctor offered advice on antibiotic prescriptions. The use of a specific antibiotic, mean duration, appropriateness of use, death within a month, source control documentation (by the surgeon), and readmission without a prior plan were the outcomes evaluated in this study.

Results: The mortality rate in the pre-ASP group was 17.30% (n = 18), while in the post-ASP group it was 14.15 (n

= 15). At p=0.69, this was statistically not significant. The pre-ASP group had a longer antibiotic duration (p<0.001). In the pre-ASP and post-ASP groups, optimal antibiotic use was observed in 23.07% (n=24) and 86.79% (n=92) of the individuals, respectively. In the pre-ASP and post-ASP groups, appropriate antibiotic selection was observed in 41.34% (n=79) of the participants, respectively (p<0.001). No patients in the pre-ASP group required source-control documentation; however, 62.26% (n=66) of the post-ASP subjects did (p<0.001).(n=43) and 74.52%

Conclusion: The current study comes to the conclusion that using ASP can improve clinical parameters related to antibiotic prescription, optimization, and duration. Additionally, in surgical individuals, perfect adherence to source- control documentation can enhance antibiotic-related variables and parameters.