A REVIEW ON MICROGLIA: ROLE IN NEUROINFLAMMATION, SCREENING MODELS AND THERAPEUTIC STRATEGIES FOR TREATMENT

Abstract

Neuroinflammation has a critical role in the pathogenesis of neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease. Microglia, the resident immune cells of the CNS play a key role in neuroinflammatory processes which have been a long subject of study in the neurodegenerative diseases. Though, the exact mechanism underlying the cause in Alzheimer and other neuroinflammatory diseases remains unresolved. The purpose of this review is to shed light in the role of microglia in neuroinflammation along with its features in Alzheimer’s disease. In this review we provide an extensive analysis of the most important and widely used in vitro and in vivo screening models for neuroinflammation. We also summarize briefly about the various natural products, nutraceuticals along with some known anti-inflammatory agents which are undergoing clinical trials and present an overview on their therapeutic potential to treat neuroinflammatory diseases.