ENHANCEMENT OF SOLUBILITY OF SIMVASTATIN BY USING LIQUISOLID COMPACT TECHNIQUE

Abstract

The present investigation was aimed to improve the dissolution rate of the poorly soluble drug simvastatin, by formulating it as a liquisolid compact. Different liquisolid compacts were prepared using mathematical formulae to calculate the required quantities of powder and liquid ingredients to produce acceptably flow able and compressible admixture. Aerosil-200, Syliod-244FP and Syliod-244FP and MCC, Lactose were employed coating and carrier material, non-volatile ((PEG 200) liquid vehicle, respectively. The various ratios of drug to liquid and carrier to coating were used to prepare liquisolid compacts. The formulated liquisolid tablets were evaluated for all pre compression and post compression parameters. The in vitro release characteristics of the liquisolid compacts as formulated by direct compression. The tableting properties of the liquisolid compacts were within the acceptable all standard limits and drug release rates were distinctly higher as compared to directly compressed tablets. The FTIR spectra showed no interaction between drug-excipient and disappearance of the characteristic absorption band of simvastatin in liquisolid formulations could be attributed to the formation of hydrogen bonding between the drug and liquid vehicle, which resulted in dissolution enhancement. Thus, the liquisolid technique was found to be a promising approach for improving the dissolution rate and solubility rate of a poorly soluble drug like simvastatin.