ACUTE RENAL FAILURE DUE TO RHABDOMYOLYSIS TREATED WITH OLMESARTAN

Abstract

Background: Myoglobinuric acute renal failure induced by glycerol injection is characterized by ischemic injury, vascular congestion, and the

appearance of reactive oxygen metabolites. This is the first study to examine the role of Olmesartan in attenuating glycerol-induced rhabdomyolysis was examined. Methods: Male Wistar rats were deprived of water for 24 hours; then given intramuscular glycerol injections intramuscularly with 10 mL/kg body weight of 50 % glycerol for group 2 and 3. Rats in group 3 were treated for 6 consecutive days with Olmesartan 3 mg/kg body weight. An hour after the last dose, a blood samples were collected so that renal function could be assessed. Then the rats were sacrificed to get kidneys, one for histological investigations, and the other for enzyme assays. Results: A significant increase in the levels of urea and creatinine, and a significant decrease in the activity of reduced glutathione was detected in glycerol-induced rats; these markers were reversed upon Olmesartan treatment. The biochemical data were supported by evaluation with kidney histopathology. All these effects induced by glycerol were attenuated upon treatment with Olmesartan. Olmesartan treatment has improved all the studied marks that induced by glycerol. Conclusion: these findings suggest that Olmesartan can significantly diminish kidney damage by glycerol.