EVALUATION OF ANTI-INFLAMMATORY ACTIVITIES OF NEWLY SYNTHESIZED ISATIN DERIVATIVES IN RATS
Keywords:
Anti-inflammatory activity., Carbamate derivatives,, , Boc-amino acid,, N-Mannich base, Isatin-3- hydrazine,, Isatin,Abstract
In search of novel anti-inflammatory agents, evaluation of anti-inflammatory activity of a series of new isatin-carbamate derivatives (3a-d) have synthesized previously by condensation isatin(2,3-indolinendione) with piperidine(hexahydropyridine), hydrazine hydrate and Boc-amino acids respectively have evaluated by using fresh egg albumin induced paw edema method. Two sources of diclofenac sodium (Olfen, Germany origin and Almiral, LIMASSOL-CYPRUS origin) as an internal standard. A majority of the synthesized compounds were showing good anti-inflammatory activity and from comparisons of these compounds, compound 3a was found to exhibit the highest anti-inflammatory activity and the chemical structures have characterized previously by IR spectroscopy and elemental analysis.
